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 Projects

 Functional anatomy and plasticity of auditory cortex

Principal investigators: Eike Budinger (PhD), Jürgen Goldschmidt (MD)
PhD students: Holger Lison, Tim Wanger
Graduate students: Julia Henschke, Jenni Neubert, Katja Saldeitis
Master students: Julia Georgi, Franziska Stöber

Collaborators within the IfN:

Dept. Auditory Learning and Speech
Dept. Behavioural Neurology
Dept. Neurochemistry and Molecular Biology

Research Group Neuroplasticity
Research Group Neuropharmacology
Research Group Neuroprostheses / BioFuture

Special Lab. Informatics
Special Lab. Laserscan- and Electronmicroscopy
Special Lab. Molecular Biological Techniques
Special Lab. Neurogenetics
Special Lab. Noninvasive Brain Imaging
Special Lab. Primate Neurobiology

Collaborators outside the IfN:

University of Bochum // Biopsychology
University of Erlangen // Otolaryngology / Pharmacology and Toxicology
University of Göttingen // Biology
University of Magdeburg // Biology / Microbiology / Neurology / Psychiatry / Psychology / Radiology
University of Munich // Anatomy, Neuroscience
University of Ulm // Neurobiology

FAN GmbH Magdeburg
Research Center Jülich / Neurosciences and Medicine

Support:

BMBF, CBBS, DAAD, DFG (SFB TRR31), LSA, WGL.

General description:

We primarily investigate the functional organization of the auditory cortex and how this organization changes during learning, behaviour and disease. We also explore and develop novel methods to gain more insight into how the cortical network operates and we use these methods for analyzing changes in the functional anatomy under normal and pathological conditions as well as in knockout models.

Experimental species are:

  • Mongolian gerbils (Meriones unguiculatus)
  • rats (Rattus norwegicus)
  • house mouse (Mus musculus), transgenic mice
  • long-tailed macaque (Macaca fascicularis)


More specifically, we study:

  • the cyto-, fiber-, and chemoarchitecture of the auditory cortex and other brain regions
  • the intrinsic and extrinsic connections of the auditory cortex and other brain regions
  • the morphology of physiologically characterized auditory cortical and thalamic neurons
  • the neuronal activity from the areal to the single cell level during several functional and pathological conditions


The most frequently applied methods are:

  • histological and immunochemical staining methods
  • anterograde and retrograde tract tracing
  • light, fluorescence, and laserscan microscopy
  • electrophysiological recordings
  • intracellular and juxtacellular cell staining
  • 2-fluoro-2-deoxyglucose-technique
  • thallium autometallography
  • SPECT

Key publications

2010

Goldschmidt, J., Wanger, T., Engelhorn, A., Friedrich, H., Happel, M., Ilango, A., Engelmann, M., Stuermer, I.W., Ohl, F.W., & Scheich H. (2010) High-resolution mapping of neuronal activity using the lipophilic thallium chelate complex TlDDC: protocol and validation of the method. Neuroimage 49, 303-315.

2009

Budinger, E., & Scheich, H. (2009) Anatomical connections suitable for the direct processing of neuronal information of different modalities via the rodent primary auditory cortex. Hear. Res. 258, 16-27.

Macharadze, T., Goldschmidt, J., Marunde, M., Wanger, T., Scheich, H., Zuschratter, W., Gundelfinger, E.D., & Kreutz, M.R. (2009) Interretinal transduction of injury signals after unilateral optic nerve crush. Neuroreport 20, 301-305.

2008

Budinger, E., Laszcz, A., Lison, H., Scheich, H., & Ohl, F.W. (2008) Non-sensory cortical and subcortical connections of the primary auditory cortex in Mongolian gerbils: Bottom-up and top-down processing of neuronal information via field AI. Brain Res. 1220, 2-32.

Jeschke, M., Lenz, D., Budinger, E., Herrmann, C.S., & Ohl, F.W. (2008) Gamma oscillations in gerbil auditory cortex during a target-discrimination task reflect matches with short-term memory. Brain Res. 1220, 70-80.

Kurt, S., Deutscher, A., Crook, J.M., Ohl, F.W., Budinger, E., Scheich, H., & Schulze, H. (2008) Auditory cortical contrast enhancing inhibition acts globally rather than locally:  Evidence for a neuronal implementation of a winner-take-all algorithm. PLOS One 3, e1735.

Schicknick, H., Schott, B.H., Budinger, E., Smalla, K.-H., Riedel, A., Seidenbecher, C.I., Scheich, H., Gundelfinger, E.D., & Tischmeyer, W. (2008) Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cereb Cortex 18, 2646-2658.


2007

Angenstein, F., Niessen, H.G., Goldschmidt, J., Lison, H., Altrock, W.D., Gundelfinger, E.D., & Scheich, H. (2007) Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice. Cereb. Cortex 17, 28-36.

Scheich, H., Brechmann, A., Brosch, M., Budinger, E., & Ohl, F.W. (2007) The Cognitive Auditory Cortex: Task-Specificity of Stimulus Representations. Hear. Res. 229, 213-224.


2006

Bernstein, H.G., Lendeckel, U., Bertram, I., Bukowska, A., Kanakis, D., Dobrowolny, H., Stauch, R., Krell, D., Mawrin, C., Budinger, E., Keilhoff, G., & Bogerts, B. (2006) Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain. Brain Res. Bull. 69, 546-559.

Budinger, E., Heil, P., Hess, A., & Scheich, H. (2006) Multisensory processing via early cortical stages: Connections of the primary auditory field with other sensory systems. Neurosci. 143, 1065-1083.

Deutscher, A., Niessen, H.G., Angenstein, F., Goldschmidt, J., Scheich, H., & Schulze, H. (2006) Comparison of estimates for volumes of brain ablations derived from structural MRI and classical histology. J. Neurosci. Methods 156, 136-139.


2005

Budinger, E., & Heil, P. (2005) Anatomy of the auditory cortex. In: Greenberg, S., & Ainsworth, W. (eds.), Listening to speech, Lawrence Erlbaum Press, New Jersey, USA, pp. 91-113.

Budinger, E (2005) Auditory cortical fields and their functions. In: König, R., Heil, P., Budinger, E., & Scheich, H. (eds.), The auditory cortex. A synthesis of human and animal research. Lawrence Earlbaum Press, New Jersey, USA, pp. 3-6.


2004

Angenstein, F., Niessen, H.G., Goldschmidt, J., Vielhaber, S., Ludolph, A.C., & Scheich, H. (2004) Age-dependent changes in MRI of motor brain stem nuclei in a mouse model of ALS. Neuroreport 15, 2271-2274.

Goldschmidt, J., Zuschratter, W., & Scheich, H. (2004) High-resolution mapping of neuronal activity by thallium autometallography. Neuroimage 23, 638-647.


2002

Brosch, M., Budinger, E., & Scheich, H. (2002) Stimulus-related gamma-oscillations in primate auditory cortex. J. Neurophysiol. 87: 2715-2725.


2000

Budinger, E., Heil, P., & Scheich, H. (2000a) Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). III. Anatomical subdivisions and corticocortical connections. Eur. J. Neurosci. 12, 2425-2451.

Budinger, E., Heil, P., & Scheich, H. (2000b) Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). IV. Connections with anatomically characterized subcortical structures. Eur. J. Neurosci. 12, 2452-2474.

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