Chemical Synapses (AG Gundelfinger)

Synaptogenetics of the human brain

Aim of this newly designed project is to correlate polymorphisms in genes encoding human synaptic proteins with differences in brain activity patterns and performance in problem solutions. The project performed in close collaboration with the Department of Neurology of the Otto von Guericke University and is organized by Bjoern Schott (OvGU) and Constanze Seidenbecher.

Fig.: A common polymorphism in the 3' region of a human neurotransmitter receptor gene affects the hemodynamic response in the prefrontal cortex of healthy subjects during deep and shallow memory encoding.

Selected publications:

Schott BH, Seidenbecher CI, Fenker DB, Lauer CJ, Bunzeck N, Bernstein HG, Tischmeyer W, Gundelfinger ED, Heinze HJ, Duzel E (2006) The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. J Neurosci 26(5):1407-1417.[Link]

found 1 datasets