Neurophysiology

Projects

1. Synaptic tagging, reinforcement of plastic changes: cellular properties

• Properties of the 'synaptic tag' [PDF 0.6 MB]
• Genes and proteins relevant for neuronal plasticity
  1. Using molecular biological techniques [PDF 0.2 MB], genes specifically up-regulated in single slices during late-LTP were isolated and its sequence was characterised, i.e. the phosphodiesterase PDE4b.
  2. The transcription factor CREB (cAMP response element binding protein) during processes of neuronal plasticity and learning
  3. The influence of Bassoon-dysfunction during normal synaptic transmission and synaptic plasticity using conventional extra- and intracellular such as patch clamp techniques.
• Cell transfection with candidate plasticity-relevant gene constructs, neuronal plasticity and two-photon-microscopy
• Presynaptic processes and LTP
• Reinforcement of LTP in vivo [PDF 0.5 MB]: Mechanisms of synaptic tagging
• Neuronal plasticity, synaptic tagging and learning [PDF 0.2 MB]
• Natural occurring firing patterns, hippocampal place cells and induction of plastic events

2. Mechanisms of neuronal plasticity related to potential pathophysiological processes

• Neuronal plasticity and learning in aged and aged-cognitively impaired animal

3. Projects funded by other organisations

BMBF

• » 2005-2008
  BMBF-Verbund "Die Rolle des Belohnungssystems des Gehirns bei der
  Handlungsüberwachung und beim Gedächtnis" TP4 (PostDoc, MTA, part.
  Doktorand) FKZ 01GW0553 an J. U. Frey

DFG

• » 2007-2010
  Heterosynaptic requirements and their implications for 'synaptic tagging' in vitro and in vivo
  FR1034_7 an J. U. Frey (PostDoc)
• » 2008-2011
  Neuromodulation hippokampaler Plastizität, 'Synaptic Tag'-Moleküle und plastizitätsrelevante Proteine: Rolle bei der selektiven Speicherung von Gedächtnisinhalten
  SFB779-B4 an J. U. Frey und S. Frey (Postdoc, HiWi)
• » 2008-2011
  Der Einfluß von Streß auf Lernen und Gedächtnis: die Rolle von Steroiden auf Verhalten und hippokampale neuronale Plastizität in der Ratte.
  KO 1540/5-1 an V. Korz und J. U. Frey (Doktorand-Äquiv., HiWi)

A-v-Humboldt Stiftung

• » 2009-2010
  Studies with hippocampal long-term potentiation on PDE4B3 inhibition and its role on NMDA and AMPA receptor functions.)

• » Fifth framework programme - Network analysis of hippocampal memory processing (European Community)
• » Multiafferente Verstärkungsmechanismen und Genexpressionsmuster bei der Konsolidierung hippokampaler Langzeitpotenzierung(DfG / BMBF)
• » The synaptic tagging hypothesis of memory trace formation: exploring the implications with respect to behaviourally expressed memory (Volkswagen Stiftung)
• » Activity-dependent gene regulation as a substrate of adaptability in neuronal networks (Volkswagen Stiftung)
• » (INTAS)
• » Emotionale und kognitive Einflüsse auf hippokampale Konsolidierungsprozesse und der Langzeitpotenzierung (LTP) in vivo (Land Sachsen Anhalt)