| Announcement |
|
In the years 2004 and 2007
the Research Group Neuroplasticity together
with the Department of Neurochemistry/Molecular Biology of the LIN has
organized two very successful meetings on synaptic development and
organization, held at the Westerburg castle, Dedeleben, Harz (http://www.westerburg-synapse.de/).
From
27th to 30th of August in 2012, the third meeting will take place in
Tangermünde at the river Elbe. Further information can be found under http://www.lin-symposium.de
|
|
|
January 2012
Marie-Curie Initial Training Network 'NPlast' operates since January 1st 2012
|
|
| On January 1st 2012 the new Marie Curie Initial Training Network (ITN) 'NPlast' started that was initiated and secured by Michael. Michael
will be the coordinator of this ITN that is entitled 'A neuroscience
school that aims to preserve and restore neuroplasticity in brain
disorders'. The NPlast consortium consists of four partners from the
private and eight partners from the public sector and will provide a
research training program for fifteen young scientists. The program
covers a broad spectrum of disorders and interventions ranging from
synaptopathies and trafficking deficiencies to Alzheimer's disease, and
from altering gene expression programs to manipulations of the
extracellular matrix of the brain to preserve or restore synaptic
function. NPlast will train young neuroscientists in relevant
techniques by bringing together expertise from different areas of
neuroscience that merge in a highly multidisciplinary research and
training program. For more information see http://www.nplast.de/ |
|
|
December 2011
|
|
|
November 2011
In Feburary 2012 Springer will publish a book with the title "Synaptic
Plasticity, Dynamics, Development and Disease" edited by Michael R.
Kreutz and Carlo Sala.
|
|
A special issue about 'Neuronal
function of EF-hand Ca2+-sensors' will be published soon in
Frontiers in Molecular Neuroscience with Michael as guest editor.
http://www.frontiersin.org/journal/viewtopics.aspx?jid=2
|
|
|
September 2011
Paper accepted in Cerebral Cortex
In a recent joint publication with the Departments of
Neurochemistry
& Molecular Biology and Auditory Learning & Speech in Cerebral
Cortex we demonstrated reorganization plasticity in the adult rat
visual system following an incomplete crush of the optic nerve.
|
Macharadze T, Pielot R, Wanger T, Scheich H, Gundelfinger
ED, Budinger E, Goldschmidt J, Kreutz MR (2011) Altered Neuronal
Activity Patterns in the Visual Cortex of the Adult Rat after Partial
Optic Nerve Crush--A Single-Cell Resolution Metabolic Mapping Study.
Cereb Cortex. 2011 Sep 21. [Epub ahead of print]
Five of the co-authors of the paper from left to right: Jürgen
Goldschmidt, Eike Budinger, Tamriko Macharadze, Michael R. Kreutz,
Eckart D. Gundelfinger. |
|
|
|
August 2011
Paper published in JBC
NPlast could show that the Ca2+-sensors
Calneuron1 and -2
are transmembrane proteins that are inserted into the ER membranes by
the TRC40/Asna-1 chaperone and that via different mechanisms accumulate
in the trans-Golgi-network.
|
Hradsky
J, Raghuram V, Reddy PP, Navarro G, Hupe M,
Casado' V, McCormick PJ, Sharma Y, Kreutz MR, Mikhaylova M (2011)
Posttranslational membrane insertion of the tail anchored transmembrane
EF-hand Ca2+-sensors Calneurons requires the TRC40/Asna1 chaperone. J
Biol Chem. 2011 Aug 30. [Epub ahead of print]
The image shows the interaction of Calneuron-1 and EYFP-TRC40/ Asna1
(green) in COS-7 cells visualized with a proximity ligation assay. Red
puncta indicate the locations where both proteins interact. The DAPI
staining (blue) is included to highlight the cell nucleus.
|
|
|
|
|
|
