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 Special Labs

 Molecular Biological Techniques

Dr. Wolfgang Tischmeyer

Head:

Dr. Wolfgang Tischmeyer

Special Lab Molecular Biological Techniques
Leibniz Institute for Neurobiology
Brenneckestraße 6
39118 Magdeburg
Germany
Phone: +49-391-6263-94291
Fax: +49-391-6263-93319
E-mail:

Long-term plastic changes in the brain, including those supporting memory formation, are assumed to depend on a sequential induction of regulatory and late structural target proteins that contribute to permanent functional alterations in neuronal cells and, in particular, their synaptic contacts. The aim of our research is the identification and functional characterization of protein components involved in phenomena of synaptic plasticity. Utilizing proteome analysis, antisense intervention in vivo, and behavioral pharmacology, the work of the Special Lab addresses the significance of defined gene products for activity-dependent plasticity in a number of animal paradigms, such as an animal model of temporal lobe epilepsy, long-term potentiation and depression, and, eventually, learning and memory formation.

Simplified model of the role of neuronal protein synthesis for memory formation.

Fig. 1: Simplified model of the role of neuronal protein synthesis for memory formation. Presentation of novel stimuli during the learning experiment leads to an early induction of regulatory proteins, such as transcrition factors of the Fos and Jun families, which in turn might initiate the expression of late effector proteins. Following maturation and transport, those proteins might contribute to terminal differentiation events necessary for the formation of long-term memory. CS : conditioned stimulus; UCS : unconditioned stimulus.

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